E. coli Bacteria Use Electricity to Grow Without Oxygen

Scientists at Rice University have made a groundbreaking discovery: bacteria that generate electricity instead of relying on oxygen to breathe!

Scientists have uncovered an amazing ability in E. coli (Escherichia coli) bacteria. Usually, these bacteria get energy by using oxygen or through fermentation when oxygen is absent. However, recent research found that E. coli can breathe using an electric electrode outside the cell instead of oxygen!

Therefore, this happens through a process called Extracellular Electron Transfer (EET). EET allows bacteria to move electrons from inside their cells to external objects like electrodes. The exciting part is that E. coli can do this using a chemical shuttle called 2-hydroxy-1,4-naphthoquinone (HNQ). HNQ carries electrons between the bacteria and an electrode. Thus, enabling growth without the usual electron acceptors like oxygen or nitrate.

The Role of Nitroreductase Enzymes in EET

The study revealed that a specific enzyme inside E. coli called NfsB nitroreductase plays a key role in this process. NfsB helps reduce HNQ by transferring electrons to it inside the cell’s cytoplasm. This reaction allows HNQ to keep cycling electrons between the bacteria and the electrode efficiently.

How Do They Do It?

These remarkable bacteria use naphthoquinones, naturally occurring compounds, to transfer electrons to external surfaces. This process, called extracellular respiration, essentially acts like a tiny battery. Hence, allowing the bacteria to thrive even without oxygen. Imagine, tiny living batteries! This is a game-changer for our understanding of bacterial metabolism.

Beyond the Lab: Real-World Applications

This isn’t just a cool scientific discovery; it has significant practical implications. Firstly, wastewater treatment and biomanufacturing could benefit immensely from this breakthrough. These electricity-producing bacteria can help manage electron imbalances, keeping these crucial systems running efficiently and sustainably. Moreover, the discovery could lead to the development of bioelectronic sensors for various applications.

Harnessing Microbial Power

The potential for clean energy is immense. Scientists believe this discovery could pave the way for harnessing carbon dioxide using renewable electricity. A process mirroring photosynthesis. Thus, this breakthrough could lead to the creation of smarter and more sustainable technologies.

A Closer Look at Energy Benefits

Furthermore, researchers used computer models to compare this new energy method with traditional fermentation pathways. They found that using HNQ-mediated EET offers more energy for bacterial growth under anaerobic (no oxygen) conditions than classic fermentation.

Why This Discovery Matters for Science and Technology

The Impact on Microbial Technologies

Thus, this discovery opens new possibilities for engineering microbes to create better bioelectronic devices or biosensors. E. coli bacteria is already widely used in biotechnology. Enabling it to grow via electrical respiration means scientists could develop new, environmentally friendly technologies. Such as microbial fuel cells or carbon capture systems.

Future Implications and Exploration

Beyond energy, this research opens doors to advancements in medical diagnosticspollution monitoring, and even deep-space exploration. Imagine using these bacteria to power sensors in harsh, oxygen-deprived environments! The possibilities are truly exciting and extend far beyond what we currently understand.

Reference

  1. Kundu, B. B., Krishnan, J., Szubin, R., Patel, A., Palsson, B. O., Zielinski, D. C., & Ajo-Franklin, C. M. (2024). Extracellular Respiration is a Latent Energy Metabolism inEscherichia coli. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2024.05.30.596743

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